They should be taken with care. To see more details on opioid medicines and alternatives for taking care of pain, stop by the healthdirect opioid medicines and pain hub.??? ????? ????? ?????? ??? ???? ?????????? ?????? ???? ????? ???????? ???????? ???? ?????????? ?? ??????? ??????? ?????????? ?????????????? ??? ????? ?? ??????? ?? ????? ???????? ??